Advance Praise

Read the Nature book review (pdf)

"Professor Walsh has selected an exceptionally important and timely topic for this book. With the completion of genome sequencing projects and emergence of the field of proteomics, researchers are, for the first time, visualizing the diversity and pervasiveness of post-translational modifications that occur on proteins. However, to my knowledge, no textbook yet exists that describes the myriad important mechanisms by which proteins are modified post-translationally and therefore this subject matter is often poorly covered in undergraduate and graduate courses.  In his book, Walsh effectively covers all of the major PTMs with a care for detail that is both admirable and captivating. The enzymes involved in generating PTMs are described with clarity and sufficient detail so that both novices and experts in this field are sure to learn much from this book.  Additionally, numerous examples of the role that PTMs play in signal transduction and metabolism are provided,  many of which I was excited to learn about for the first time."
---Benjamin F. Cravatt III, The Skaggs Institute for Chemical Biology, The Scripps Research Institute

"This book covers the wide range of posttranslational modifications found in Nature, many of which have been discovered relatively recently as a result of improved detection methods. As such, it is a very timely book that may be used either as a reference entry into a certain field or as a comprehensive collection of the astonishing structural and functional variety of these modifications. The author treats the subject from the perspective of both the mechanism of formation of these protein conjugates and their biological function in processes like signal transduction and enzymatic catalysis. As expected from Walsh, each topic is treated clearly with an eye for important details as well as the more overarching implications. Several very interesting links are made between various modification processes and their roles in biological processes that tie the at first glance heterogeneous collection of posttranslational modifications very nicely together."
---Wilfred van der Donk, University of Illinois at Urbana-Champaign

"The central dogma of gene -> protein -> function has suffered continuing amendments by protein posttranslational modifications.  Walsh brings expert skills in enzymology, protein function and not least, clear writing to this succinct overview of a burgeoning field. This book deserves a place on the desk of every serious student (and professional) of metabolism, protein structure and cellular signaling. A highlight for this reviewer is the attention to posttranslational regulation as targets for pharmaceutical intervention. Walsh does a superb job of weaving whole fabric from these still-developing pathways."
---Vern L. Schramm, Ruth Merns Chair and University Professor, Albert Einstein College of Medicine